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快讯,据上海财经大学研究生院消息,2015年上海财经大学0714Z2经济统计学考研报录比已发布,详情如下:学院名称专业代码专业名称报考情况(不含推免)录取情况报考人数实考人数总录取人数其中推荐免试录取统计与管理学院0714Z2经济统计学109955 更多
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高艳锋,副教授,硕士生导师。2001年毕业于兰州大学生命科学学院生物学基地班,获理学学士学位。2006年毕业于兰州大学生命科学学院生物化学与分子生物学专业,获理学博士学位。2006年7月进入郑州大学生命科学学院,主要从事肿瘤免疫与多肽药物研究。河南省生物化学与分子生物学会秘书长,河南省杰出青年基金获得者,河南省优秀中青年骨干教师,郑州大学青年骨干教师。CancerLetters,Bioorganic&MedicinalChemistryLetters,Peptides,Protein&PeptideLetters和JournalofFoodBiochemistry等SCI杂志的审稿人。ChineseJournalofBiology杂志编委。承担课题:[1]国家自然科学基金(81172893)(主持):PD-1/PD-L1拮抗肽的筛选及其在肿瘤免疫治疗中的应用研究,起止年月:2012年~2015年[2]国家自然科学基金(30901362)(主持):乳腺癌PIWIL2、PLAC1抗原HLA-A2限制性CTL表位鉴定以及综合改造策略研究,起止年月:2010年~2012年[3]河南省杰出青年基金(主持)(134100510015):新型抗肿瘤多肽AS16的研究与开发,起止年月:2013年~2015年[4]河南省青年骨干教师资助计划(2010GGJS-016)(主持):靶向细胞周期的新型抗肿瘤多肽的设计与活性研究,起止年月:2010年~2012年[5]河南省基础与前沿技术项目(102300410077)(主持):基于MazEF复合物的新型抗菌肽的设计、合成与构效关系研究,起止年月:2010年~2012年[6]河南省医学科技攻关项目(201003008)(主持):基于CT抗原的乳腺癌HLA-A2限制性抗原肽表位的筛选,起止年月:2010年~2012年[7]河南省科技攻关项目(072102330038)(主持):新型肿瘤抗原肽和广谱疫苗的研究,起止年月:2007年~2009年[8]河南省医学科技攻关项目(200703013)(主持):基于Cyclin/CDK复合物结构的抗肿瘤多肽的研究,起止年月:2007年~2009年[9]“十二五”科技部“重大新药创制”重大专项(2012ZX09103301-023)(副组长):新型抗肿瘤多肽药物AS16的研制,起止年月:2012年~2015年[10]河南省重点科技攻关项目(112102310068)(第2):结核耐药相关抗原CTL表位的筛选与疫苗研制.起止年月:2011年~2013年[11]河南省杰出人才计划项目(084200510014)(第2):结核病抗原肽表位的筛选和多价疫苗的研制.起止年月:2008年~2010年发表的主要论文:[1]HailiWang,XiChen,YanpingChen,LeiSun,GuodongLi,MingxiaZhai,WenjieZhai,QiaozhenKang,YanfengGao*,YuanmingQi*.AntitumoractivityofnovelchimericpeptidesderivedfromcyclinD/CDK4andtheproteintransctiondomain4.AminoAcids,2013,44(2):499-510.[2]JiZ,ShiX,LiuX,ShiY,ZhouQ,LiuX,LiL,JiX,GaoY,QiY,KangQ.Themembrane-cytoskeletalprotein4.1Nisinvolvedintheprocessofcelladhesion,migrationandinvasionofbreastcancercells.ExpTherMed.2012,4(4):736-740.[3]YahongWu,YanfengGao*,YujieHe,RanranShi,MingxiaZhai,ZongyinWu,MengSun,WenjieZhai,XiChen,YuanmingQi*.AnovelcytotoxicTlymphocyteepitopeanaloguewithenhancedactivityderivedfromcyclooxygenase-2.ScandJImmunol.2012,76(3):278-85.[4]ChaoDai,ZhaoqingXu*,FeiHuang,ZhengkunYu*,Yan-FengGao*.LewisAcid-Catalyzed,Copper(II)-MediatedSynthesisofHeteroarylThioethersunderBaseFreeConditions.JournalofOrganicChemistry.2012,77(9):4414-9.[5]FeiChen,MingxiaZhai,YuhuangZhu,YuanmingQi,WenjieZhai,YanfengGao*.InvitroandinvivoidentificationofanovelcytotoxicTlymphocyteepitopefromRv3425ofMycobacteriumtuberculosis.MicrobiologyandImmunology.2012,56(8):548-53.[6]ZongyinWu,YanfengGao*,YahongWu,WeiLiu,MengSun,MingxiaZhai,YuanmingQi,YongYe.IdentificationofanovelCD8+Tcellepitopederivedfromcancer-testisantigenMAGE-4inoesophagealcarcinoma.ScandJImmunol.2011,74:561-567.[7]WeiLiu,MingxiaZhai,ZongyinWu,YuanmingQi,YahongWu,ChaoDai,MengSun,LuLi,YanfengGao*IdentificationofanovelHLA-A2-restrictedcytotoxicTlymphocyteepitopefromcancer-testisantigenPLAC1inbreastcancer.AminoAcids.2012,42(6):2257-65.[8]Yu-huangZhu,Yan-fengGao*,FeiChen,WeiLiu,Ming-xiaZhai,Wen-jieZhai,Yuan-mingQi*,YongYe.IdentificationofnovelTcellepitopesfromeffluxpumpsofMycobacteriumtuberculosis.ImmunologyLetters.2011,140(1-2):68-73.[9]Jun-weiZhao,Zhan-qiangSun,Hong-guoYang,Chong-zhenZhangandXiao-liYu,Zi-luWen,Yan-fengGao,Xiao-kuiGuo,Yuan-mingQi,Shu-linZhang.Cloning,expressionandimmunologicalevaluationofashortfragmentfromRv3391ofMycobacteriumtuberculosis.AnnalsofMicrobiology,2011,61(2):345-353.[10]HongLv,Yan-fengGao*,Ya-hongWu,Ming-xiaZhai,LuLi,Yu-huangZhu,WeiLiu,Zong-yinWu,FeiChen,Yuan-mingQi.IdentificationofanovelcytotoxicTlymphocyteepitopefromCFP21,asecretedproteinofMycobacteriumtuberculosis.ImmunologyLetters.2010,133(2):94-8.[11]YanfengGao*,KunChen,BinZhang,XiangLi,LuChen,YuanjunLi,XiangjiaoJia,YongxingLei,ZhongyiYan,LiangliangKong,NanWang,WeiLiu,YuanmingQi.AntioxidantandfreeradicalscavengingactivityoftheextracellulardeathfactorinEscherichiacoli.Peptides,2010,31(10):1821-1825.[12]Dong-dongWu,Yan-fengGao,Li-xiangChen*,Yuan-mingQi*,Qiao-zhenKang,Hai-liWang,Lin-yuZhu,YongYe,Ming-xiaZhai.Anti-tumoreffectsofanovelchimericpeptideonS180andH22xenograftsbearingnudemice.Peptides.2010,31(5):850-864.[13]Yan-fengGao,Zhan-qiangSun,FengQi,Yuan-mingQi*,Ming-xiaZhai,Hui-pingLou,Li-xiangChen,Yong-xinLi,Xian-yuanWang.Identificationofanewbroad-spectrumCD8+Tcellepitopefromover-expressedantigenCOX-2inesophagealcarcinoma.CancerLetters,2009,284(1):55-61.[14]Hui-pingLou,Yan-fengGao*,Ming-xiaZhai,Yuan-mingQi*,Li-xiangChen,HongLv,Ji-bingYu,Yong-xinLi.Anovelpeptidefromα5helixofAsterinapectiniferacyclinBconjugatedtoHIV-Tat49–57withcytotoxicandapoptoticeffectsagainsthumancancercells.Bioorganic&MedicinalChemistryLetters,2008,18(16):4633-4637.[15]Yan-fengGao,Ming-xiaZhai,Wei-xiaLiu,XinLiu,YeYuan,Yuan-mingQi*,RuiWang*.Structure-activityrelationshipsofthedimericanaloguesofendomorphin-2withdifferentlengthsofspacers.Protein&PeptideLetters,2008,15(3):275-279.[16]Chang-FengHu,Chuan-JunZhu,Yan-FengGao,XuanShao,RuiWang,Yu-XinCui.CharacteristicFragmentationBehavioroftheAnalogsofendomorphin-2withPhenylglycineinPosition3or4byESI-FTTandemMassSpectrometry.ChineseChemicalLetters.2008,19(12):1479-1482.[17]YunFeng,Ying-weiLu,XinLin,Yan-fengGao,Qian-yuZhao,WeiLi,RuiWang*.Endomorphinsandmorphinelimitanoxia-reoxygenation-incedbrainmitochondrialdysfunctioninthemouse.LifeSciences,2008,82(13-14):752-763.[18]XuanShao,Yan-fengGao,Chuan-junZhu,Xue-huiLiu,Jin-longYao,Yu-xinCui,RuiWang*.Conformationalanalysisofendomorphin-2analogswithphenylalaninemimicsbyNMRandmolecularmodeling.Bioorganic&MedicinalChemistry,2007,15(10):3539-3547.[19]Li-xiangChen,Yuan-mingQi*,RuiWang*,XinDuan,Yan-fengGao,Ding-jianYang.Rolesofnitricoxidesynthaseinhibitoronantinociceptiveeffectsofμ-Opioidagonistinmice.Protein&PeptideLetters,2006,13(10):993-997.[20]Yan-fengGao,XinLiu,Wei-xiaLiu,Yuan-mingQi,Xue-fengLiu,RuiWang*.Opioidreceptorbindingandantinociceptiveactivityoftheanaloguesofendomorphin-2andmorphiceptinwithphenylalaninemimicsintheposition3or4.Bioorganic&MedicinalChemistryLetters,2006,16(14):3688-3692.[21]Yan-fengGao,XinLiu,JieWei,Bei-beiZhu,QiangChen,RuiWang*.Structure-activityrelationshipofthenovelbivalentandC-terminalmodifiedanaloguesofendomorphin-2.Bioorganic&MedicinalChemistryLetters,2005,15(7):1847-1850.[22]JieWei,XuanShao,Mao-zhenGong,Bei-beiZhu,Yu-xinCui,Yan-fengGao,RuiWang*.Structure-activityrelationshipsofnovelendomorphin-2analogueswithN-Oturnsincedbyα-aminoxyacids.Bioorganic&MedicinalChemistryLetters,2005,15(12):2986-2989.[23]Yi-fengZhou,RuiWang*,Zhao-qingXu,Wen-jinYan,LeiLiu,Yan-fengGao,Chao-shanDa.Boc-L-prolineasanewchiralligandforenantioselectivephenylacetyleneadditiontoaromaticaldehydes.Tetrahedron:Asymmetry.2004,15(4):589-591.[24]XinLin,Ding-jianYang,Wen-qingCai,Qian-yuZhao,Yan-fengGao,QiangChen,RuiWang*.Endomorphins,endogenousopioidpeptides,provideantioxidantdefenseinthebrainagainstfreeradical-inceddamage.BiochimicaetBiophysicaActa(BBA)-MolecularBasisofDisease,2003,1639(3):195-202.专利:[1]PLAC1抗肿瘤CTL表位肽及其应用.专利授权号:ZL201010205684.0[2]PIWIL2抗肿瘤CTL表位肽及其应用.专利授权号:ZL201010276917.6[3]抗结核CTL表位肽.专利授权号:ZL200910065403.3.[4]MAGE-4抗肿瘤CTL表位肽及其应用.专利授权号:ZL201010212512.5[5]结核分枝杆菌抗原限制性表位肽.专利授权号:201010030225.3.[6]结核耐药相关外排蛋白来源抗结核CTL表位肽及其应用.专利授权号:201110138646.2[7]MTA1来源的抗肿瘤CTL表位肽及其应用.专利授权号:201110138635.4[8]PL2L60来源的CTL表位肽及其应用.专利授权号:201210001557.8教材:[1]祁元明主编,高艳锋,张守涛副主编.生物化学实验原理与技术,化学工业出版社,2011.普通高等教育“十二五”规划教材。[2]UnderstandingTuberculosisIV:AnalyzingtheoriginofMycobacteriumtuberculosispathogenicity,InTechPress,2012,参编。获奖情况:[1]第十一届中国国际多肽会“YongPeptideScientistAward”[2]河南省医学科技进步一等奖和河南省科技进步二等奖[3]“沈琼食管癌研究奖励基金”优秀科研成果二等奖[4]河南省教学技能大赛二等奖[5]河南省自然科学优秀论文一等奖2项[6]河南省自然科学优秀论文二等奖4项[7]郑州大学“三育人”先进个人[8]河南省《生物化学》教学团队,主要完成人[9]《生物化学》校级精品课程,主要完成人[10]郑州大学“挑战杯”课外学术科技竞赛评审委员会委员[11]2007和2010年度郑州大学“挑战杯”活动特等奖和二等奖,指导教师[12]河南省优秀硕士学位论文,指导教师*如果发现导师信息存在错误或者偏差,欢迎随时与我们联系,以便进行更新完善。联系方式>> 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