虹霓关
张海林的简介 性别:男 学位:博士 职称:教授 职务:河北医科大学药学院副院长,基础医学研究所药理研究室主任 研究方向: 内向整流钾离子通道的结构与功能 信号传导的分子机制 离子通道功能的调节 分子生理学,分子药理学及神经生物学个人履历 1984年毕业于河北医科大学医学专业,获学士学位;1987年在获河北医科大学药理学硕士学位;1995年在英国伦敦大学圣乔治医学院(St. George’s Hospital Medical School)药理系获博士学位。曾先后在英国伦敦大学、美国霍华德休斯医学研究所(Howard Hughes Medical Institute)、美国纽约大学西奈山医学中心(Mount Sinai Medical Center)进行博士后研究,2000年起任职于西奈山医学中心生理与生物物理系。2001年10月以特殊人才受聘于河北医科大学。现为河北医科大学药 理教研室教授,燕赵学者,博士生导师,药学院副院长,基础医学研究所药理研究室主任,基础医学院药理教研室副主任。主要从事离子通道的结构与功能关系、细 胞信号传导及对离子通道的调节机制研究。已在包括《Nature Cell Biology》, 《Neuron》, 《Nature Neuroscience》, 《EMBO》, 《J. Biol. Chem.》等国际专业杂志上发表科研究论文多篇。燕赵学者,获国家杰出青年科学基金,并主持美国国家卫生研究院(NIH)国际合作基金项目、科技部重大 基础研究前期研究专项、国家自然科学基金、教育部重点项目等。2005年河北省十大科技杰出青年获得者。重要学术论文 1. Peng LY, Mirshahi T., Zhang HL., Hirsch J. and Logothetis DE (2003) Critical Determinants of the G Protein g Subunits in the Gbg Stimulation of G Protein-actiated Inwardly Rectifying Potassium (GIRK) Channel Actiity. J Biol Chem 278 (50), 50203–50211, 2. Chan KW, Zhang HL and Logothetis1 DL (2003) N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. The EMBO Journal, 22 (15) 3833-3843 3. Zhang H., Craciun LC, Mirshahi T, Rohács T, Lopes CMB, Jin T, and Logothetis DE. (2003) PIP2 Actiates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents. Neuron, 37(6), 963-975 4. Lopes C M.B., Zhang H., Rohacs T, Jin T, Yang, J. and Logothetis D.E. (2002) Alterations in Consered Kir Channel-PIP2 Interactions Underlie Channelopathies. Neuron, 34, 933–944 5. Perez CA., Huang L., Rong M., Kozak JA., Zhang H., Max M. and Margolskee RF. (2002). A transient receptor potential channel expressed in taste receptor cells. Nature Neurosci. 5(11):1169-76. 6. Mirshahi T, Mittal , Zhang H, Linder ME, Logothetis DE. (2002) Distinct sites on G protein beta gamma subunits regulate different effector functions. J Biol Chem 277(39):36345-50. 7. He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (2002) Identification of critical resies controlling G protein-gated inwardly rectifying K(+) channel actiity through interactions with the beta gamma subunits of G proteins. J Biol Chem 277:6088-96 8. Mirshahi T, Robillard L, Zhang H, Hebert TE, Logothetis DE (2002) Gbeta resies that do not interact with Galpha underlie agonist-independent actiity of K+ channels. J Biol Chem 277(9):7348-55 9. Rohac T., Lopes CMB., Mirshahi T., Jin T., Zhang H. & Logothetis DE. (2001). Assay pf phosphatidylinositol biphosphate regulation of potassium channels. In G protein pathways, part C: Effector mechanism. Methods in Enzymology, 345-357 10. Hughes TE, Zhang, HL, Logothetis DE, Berlot CH (2001). isualization of a functional Gaq-green fluorescent protein fusion in liing cells: Association with the plasma membrane is disrupted by mutational actiation and by elimination of palmitoylation sites, but not by actiation mediated by receptors or AlF4- . J Biol Chem, 276:4227-4235. 11. Kobrinsky E, Mirshahi T, Zhang H, Jin T, Logothetis DE (2000). Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization. Nature Cell Biology, 2:507-14. 12. Zhang,HL., He C., Yan XX, Mirshahi T and Logothetis DE. (1999) Actiation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology, 1:183-188 13. He, C., Zhang, HL., Mirshahi, T. and Logothetis, D. (1999). Specific Gbg Interaction With a K+ Channel Distinguish Between Basal and Agonist-inced Currents. J. Bio. Chem, 274:12517-12524 14. Logothetis, E.D. & Zhang, HL. (1999) Gating of G protein-sensitie inwardly rectifying K+ channels through phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J. Physiol. London, 520, 630 15. Zhang, H-L., T. B. Bolton, A. E. Piekarska & G. A. McPherson (1998). The electrophysiological effects of tetraphenylphosphonium and tetraphylboron on ascular somooth muscle. Eur. J. Pharmacol, 347(1), 119-23 16. Zhang, H-L & Bolton, T. B. (1996) ATP-sensitie potassium channels and their molation by nucleotides and potassium channel openers in ascular smooth muscle cells. In: Smooth muscle excitation. Eds: Bolton T. B. & Tomita, T. Academic Press Limited. Chapter 12, pp 139-154 17. Zhang, H-L. & Bolton, T. B. (1996). Two types of ATP-sensitie potassium channels in rat portal ein smooth muscle cells. Br. J. Pharmacol. 118, 105-114 18. Zhang, H-L. & Bolton, T. B. (1995). Effects of UK-84149 on oltage-actiated calcium currents of single smooth muscle cells from guinea-pig and rabbit jejunum and rabbit coronary. Br. J. Pharmacol., 114, 1657-1665 19. Zhang, H-L. & Bolton, T. B. (1995). Actiation by Intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitie K-channel in smoothmuscle cells of rat mesenteric artery. Br. J. Pharmacol., 114, 662-672 20. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). Single channel and whole-cell K-currents eoked by lecromakalim in smooth muscle cells from the rabbit portal ein. Br. J. Pharmacol., 110, 583-590. 21. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). K channel actiation by nucleotide diphosphates and its inhibition by glibenclamide in ascular smooth muscle cells. Br. J. Pharmacol., 110, 573-582 著作 A text book of fundamental medical pharmacology (英文), 编委,吉林科学技术出版社, 2004承担课题 1. 国家杰出青年科学基金 (30325038), 2004.1-2007.12 2. 美国国家卫生研究院NIH Fogarty 国际合作项目(1 R03 TW006020-01A1): Protein Kinase C-dependent inhibition of Kir channels, 2003.4-2006.4, 3. 科技部基础研究重大项目前期研究专项(2003CCA00300):细胞膜磷脂对离子通道功能的调节及其生理学意义, 2003.12-2005.12 4. 国家自然科学基金项目(30270361): 膜磷脂PIP2对M电流及KCNQ电流的调节作用. 2003.1-2005.12, 5. 河北省自然科学基金项目。磷脂酰肌醇二磷酸对M电流的调节及生理学意义(303464),2003.1-2005.12 6. 国家自然科学基金项目(30240001): 老年大鼠M电流的研究. 2002.1---2002.12, 7. 教育部科学技术研究重点项目(02016): pH调节内向整流钾离子通道功能的分子机制, 2002.1-2003.12 最近完成的工作主要是有关膜磷脂PIP2在调节钾离子通道功能作用方面的研究,主要包括以下几 个部分:(1)提出并证明了PIP2可作为生理性调节的、影响钾离子通道的直接信号分子这一新的概念。(2)提出并证明了钾离子通道中氨基酸突变所造成的 通道蛋白-PIP2分子间反应的改变是导致遗传性疾病Andersen 综合症及Barters综合症的分子基础;(3)证明PIP2对于维持神经细胞M电流和KCNQ通道的功能至关重要,而神经递质诱发M电流和KCNQ通道 抑制的机制是由于它们共有的导致PIP2水解所为;(4)提出并证明了通道蛋白-PIP2反应特征决定了pH、PKC、Mg2+ 等调节Kir钾通道的特征,提出了通道蛋白-PIP2反应可能是决定各种调节因素调节通道功能的共有的关键机制的新观点。许彦芳的简介可以打河北医科大学研究生学院阅览把网址给你粘贴到这儿吧 http://202.206.48.96:8080/gmis/xkjsb/yjsdsfc.aspx?id=1030令:2011年二人均在石家庄市长安区竞选人大代表(二人中选一个),我们参加了投票,不知结果如何普遍认为张海林更胜一筹,但你要结合你的研究方向选个最适合你的啊,祝你好运!!!