姓名：周天华职务：基础医学系副主任职称：教授学历：博士专业：细胞生物学、病理学与病理生理学所属院系：基础医学系研究方向：分子细胞生物学、胃肠肿瘤学个人简介周天华，男，1970年出生，博士，教授，博士生导师，“教育部新世纪优秀人才计划”获得者。1993年获浙江大学医学院临床医学学士学位，1996年获浙江大学医学院临床医学硕士学位，1999年获中国科学院上海生命科学院生物化学和细胞生物学研究所理学博士学位。2000年赴美国哈佛大学分子细胞生物学系进行博士后训练，于2005年回国在浙江大学医学院任教，现任浙江大学基础医学系副主任。周天华博士在分子细胞生物学和分子肿瘤学等领域，具有比较扎实的理论知识和实践基础，自1997年以来，已在《DevCell》（Cell子刊）、《PNAS》（美国国家科学院院刊）和《JBiolChem》等国际学术期刊发表了29篇原始学术论文，合计影响因子超过140，受到国际同行们的关注（已被国际学术杂志引用了数百次）。国际权威杂志NatureReviewsMolecularCellBiology曾经以新闻的方式报道过其工作，由世界知名生物医学科学家组成的独立同行评议服务机构Facultyof1000，也专门推荐其研究成果。2009年起，其领导的研究小组在细胞运动分子机理调控及人类重大疾病发生发展的细胞运动基础等领域，取得了一些有价值的实验结果，在《PNAS》和《JBiolChem》等国际著名刊物上发表了一系列的原创性学术文章。其研究工作受到国家自然科学基金、国家高技术研究发展计划（863计划）、国家重点基础研究发展计划（973计划）等项目的资助。主要学术兼职：中国细胞生物学学会精细细胞结构与功能分会秘书长浙江省细胞生物学学会常务理事CellResearch（影响因子9.417）编委近年来发表主要原始论文：作为通讯作者和第一作者的主要论文（*通讯作者）：1.XuY,DengY,YanXandZhouT*．TargetingmiR-375ingastriccancer．ExpertOpiniononTherapeuticTargets．(doi:10.1517/14728222.2011.581232)May2011.（最新影响因子:3.649）2.ZhuX,LiuX,JinQ,CaiY,YangYandZhouT.*(2010)．TheL279PMutationofNuclearDistributionGeneC(NudC)InfluencesItsChaperoneActivityandLIS1Stability．JournalofBiologicalChemistry285(39):29903-29910．(最新影响因子:5．328)3.DingL,XuY,ZhangW,DengY,SiM,DuY,HaoH,LiuX,SiJandZhouT.*(2010)．MiR-375FrequentlyDown-regulatedinGastricCancerInhibitsCellProliferationbyTargetingJAK2．CellResearch20(7):784-793．(最新影响因子:9.417)4.YangY,YanX,CaiY,LuY,SiJ*andZhou,T.*(2010)．NudC-likeprotein2regulatestheLIS1/dyneinpathwaybystabilizingLIS1withHsp90．ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica107(8):3499-3504．(最新影响因子:9.771)5.CaiY,YangY,ShenMandZhouT.*(2009)InhibitionofcytokinesisbyoverexpressionofNudCLthatislocalizedtothecentrosomeandmidbody．CellResearch19(11):1305-1308．(当年影响因子:8.151)6.DuY,XuY,DingL,YaoH,YuH,ZhouT*andSiM.*(2009)Down-regulationofmiR-141ingastriccanceranditsinvolvementincellgrowth．JournalofGastroenterology44(6):556–561．(当年影响因子:2.909)7.ZhouT,ZimmermanW,LiuXandEriksonRL．(2006)．AMammalianNudC-LikeProteinEssentialforDyneinStabilityandCellViability．ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica103(24):9039-9044．(当年影响因子:9.643）8.ZhouT,*AumaisJ,LiuX,Yu-Lee,LYandErikson,RL．(2003)．AroleforPlk1phosphorylationofNudCincytokinesis．DevelopmentalCell5(1):127-138．(当年影响因子:14.807）9.ZhouTH,LingK,GuoJ,ZhouH,WuY,JingQ,MaLandPeiG．(2000)．Identificationofahumanbrain-specificisoformofmammalianSTE20-likekinase3thatisregulatedbycAMP-dependentproteinkinase．JournalofBiologicalChemistry275(4):2513-2519．(当年影响因子:7.368）10.WuGX,#LinYM,#ZhouTH,#GaoHandPeiG．(2000)．Significantdown-regulationofalpha-albumininhumanhepatomaanditsimplication．CancerLetters160(2),229-236．(#共同第1作者，当年影响因子:1.517）11.ZhouTH,RenXH,YinDL,WuYL,LiM,LuCZ,WuDC,WuYQ,PengYQ,WangYP,MaLandPeiG．(1997)．Retardationofpaindevelopment:acaseofrecoveryfromcongenitalinsensitivitytopain．ActaAnaesthesiologicaScandinavica41,1077-1079．(当年影响因子:1.953）作为合作作者的主要论文：12.GanL,ChenS,ZhongJ,WangX,EKLam,LiuX,ZhangJ,ZhouT,YuJ,SiJ,WangL,andJinH．(2011)．ZIC1isdownregulatedthroughpromoterhypermethylation,andfunctionsasatumorsuppressorgeneincolorectalcancer．PloSOne6(2):e16916．(最新影响因子:4.610)13.ZhouQ,LuX,GanL,ChenS,ZhouT,WangLandSiJ．(2010)．RoleofREGIαingastriccarcinogenesis:Gastrin-associatedproliferativeandanti-apoptoticactivities．MolecularMedicineREPORORTS3(6):999-1005．(最新影响因子:0.307)14.LiA,ZhouT,GuoL,SiJ．(2010)CollagentypeIregulatesbeta-catenintyrosinephosphorylationandnucleartranslocationtopromotemigrationandproliferationofgastriccarcinomacells．OncologyReports23(5):1247-1255．(最新影响因子:1.686)15.ZhaoY,ZhouT,YaoH,HeiF,WangLandSiM．(2009)APotentialRoleofCollagensExpressioninDistinguishingbetweenPremalignantandMalignantLesionsinStomach．TheAnatomicalRecord292(5):692-700．(当年影响因子:1.490)16.ChenY,ChenY,LiuWL,ZhouTH,CaiJT,DuQ,WangLJ,WuJGandSiJM．(2009)．Therapeuticeffectsofrectaladministrationofmuscoviteonexperimentalcolitisinrats．JournalGastroenterologyandHepatology24(5):912-919．(当年影响因子:2.317)17.PanH,ShengJZ,TangL,ZhuR,ZhouTHandHuangHF．(2008)．Increasedexpressionofc-fosproteinassociatedwithincreasedmatrixmetalloproteinase-9proteinexpressionintheendometriumofendometrioticpatients．Fertility&Sterility90(4):1000-1007．(当年影响因子:4.167)18.LiM,ZhouTH,GaoY,ZhangNandLiJC．(2007)．Ultrastructureandestrogenregulationofthelymphaticstomataofovarianbursainmice．TheAnatomicalRecord290(10):1195-1202．(当年影响因子:1.800）19.LiuWL,ChenSJ,ChenY,SunLM,ZhangW,ZengYM,ZhouTHandSiJM．(2007)．Protectiveeffectsofheatshockprotein70incedbygeranylgeranylacetoneinatrophicgastritisinrats．ActaPharmacologySinica28(7):1001-1006．(当年影响因子:1.677）20.LiuAX,JinF,ZhangWW,ZhouTH,ZhouCY,YaoWM,QianYLandHuangHF．(2006)．Proteomicanalysisonthealterationofproteinexpressionintheplacentalvilloustissueofearlypregnancyloss．BiologyofReproction75(3):414-420．(当年影响因子:3．498）21.LiuX,LinCY,LeiM,YanS,ZhouTandEriksonRL．(2005)．CCTchaperonincomplexisrequiredforthebiogenesisoffunctionalPlk1．MolecularandCellularBiology25(12):4993-5010.（当年影响因子:7.093）22.LiuX,ZhouT,YanSandEriksonRL．(2004)．Molecularinteractionofpolo-likekinase1withmitotickinesin-likeproteinCHO1/MKLP-1．JournalofCellScience117(15):3233-3246．(当年影响因子:6.910）23.LiuX,YanS,ZhouT,TeradaYandEriksonRL．(2004)．TheMAPkinasepathwayisrequiredforentryintomitosisandcellsurvival．Oncogene23(3):763-776．(当年影响因子:6.318）24.WangP,WuY,ZhouTH,SunYandPeiG．(2000)．IdentificationofalternativesplicingvariantsofthebetasubunitofhumanCa(2+)/calmolin-dependentproteinkinaseIIwithdifferentactivities．FEBSLetters475(2):107-110．(当年影响因子:3.440）25.YuQM,ChengZJ,ZhouTH,CenB,GuoSQandPeiG．(1999)．Molecularcloningofhumanbetaarrestin1cDNA,expressionandfunctionstudy．ActaBiochimicaetBiophysicaSinica31(3):344-346．(最新影响因子:1.547）26.LouLG,ZhouT,WangPandPei,G．(1999)．MolationofCa2+/Calmolin-DependentProteinKinaseIIActivitybyAcuteandChronicMorphineAdministrationinRatHippocampus:DifferentialRegulationofandIsoforms．MolecularPharmacology55(3):557-563．(最新影响因子:4.725）27.FanGH,ZhouTH,ZhangWBandPeiG．(1998)．SuppressionofPhospholipaseCblocksGi-mediatedinhibitionofadenylylcyclaseactivity．EuropeanJournalofPharmacology341(2),317-322．(最新影响因子:2.737）28.YuQM.,ChengZJ,ZhaoJ,ZhouTH,WuYLMaLandPeiG．(1998)．Carboxylterminalofrhodopsinkinaseisrequiredforthephosphorylationofphoto-activatedrhodopsin．CellResearch8(4),:303-310．(最新影响因子:9.417）29.WuYL,FanGH,ZhaoJ,ZhouTH,MaLandPei,G．(1997)．FunctionalexpressionofOpioidreceptor-likeReceptoranditsendogenousspecificagonistNociceptin/OrphaninFQringMouseembryogenesis．CellResearch7(2):207-215．(最新影响因子:9.417）英文著作：1．Zhou,T．andErikson,R.L．AroleofPolo-likekinase1phosphorylationofNudCincytokinesis．InSignalTransctionofCellDivision,T．Miki,ed．(ResearchSignpost)．(2005).在美国基因数据库(GenBank)登录的基因：FJ215684(HomosapiensNudC-likeprotein2),AF083420(homosapiensbrain-specificSTE20-likeproteinkinase3,MST3b),AF078803(homosapienscalcium/calmolin-dependentproteinkinase2betasubunit),AF081924(homosapienscalcium/calmolin-dependentproteinkinase2beta6subunit),AF140350(Homosapienscalcium/calmolin-dependentproteinkinaseIIbeta7subunit),AF083419(homosapienscalcium/calmolin-dependentproteinkinasebeta2esubunit),AF081572(homosapienscalcium/calmolin-dependentproteinkinase2betae’subunit),AF091486(homosapienscalcium/calmolin-dependentproteinkinase2alphasubunit),AF084040(homosapiensbeta-arrestin1A),AF084940(homosapiensbeta-arrestin1B),AF106941(homosapiensbeta-arrestin2)．相关获奖成果：1、胃癌前病变癌变准确监测和有效阻断技术体系的建立（2009年中华医学科技奖、排名第三）相关专利：1．美国专利“Methodfordetectinglivercellinperipheralblood”（专利证书号：CN1331417-A，排名第三）