姓名：吴华悦性别：男出生年月：1962年3月职称：教授所在学院：数学与信息科学学院个人简介吴华悦，男，汉族，1962年3月生，浙江兰溪，中共党员，教授，硕士研究生导师。1984毕业于杭州大学化学系有机化学专业，同年进入温州师范学院任教，现任温州大学有机及药物化学研究所所长，有机化学硕士点负责人，浙江省新药创制平台理事会理事，浙江省新药创制科技服务平台温州工作站负责人。入选温州市“新世纪551人才工程”第一层次、温州大学“高级人才工程”，获温州大学“教坛名师”称号。指导的研究生硕士论文入选2008年度浙江省优秀硕士论文。主持和参加国家“十一五”科技支撑计划项目、国家自然科学基金等国家、省部级科研项目多项，已在Org．Lett．;J．Org．Chem．;GreenChem．;Tetraherdon;Synlett;TetraherdonLett．;Synthesis等国内外刊物上发表SCI论文60余篇，申请专利20余项，其中授权发明专利4项。获浙江省科学技术奖2项，目前正从事药物及中间体的合成研究和有机合成方法学研究，是省、市重大科技项目的评审专家。2009年被EncyclopediaofReagentsforOrganicSynthesis创刊编辑LeoA．Paquette邀请撰写其中部分章节（PreparationandApplicationofTris-1-naphthylPhosphine），被J．Org．Chem．;GreenChem．和Tetrahedron等期刊选为审稿人。代表论著1．JiuxiChen,*YongPeng,MiaochangLiu,JinchangDing,HuayueWu,*Palladium-catalyzedaerobicoxidativecouplingofacylchlorideswitharylboronicacids,Adv．Synth．Catal．2012accepted．SCI-TOP2．QuanshengDing,JileiZhang,JiuxiChen,*MiaochangLiu,JinchangDing,HuayueWu,*Tandemsynthesisof2,3-dihydroquinazolin-4(1h)-onesongrindingundersolvent-freeconditions,J．HeterocyclicChem．2012,inpress．SCI3．GaigaiLiang,MiaochangLiu,JiuxiChen,*JinchangDing,WenxiaGao,HuayueWu,*NBS-promotedsulfenylationofsulfinateswithdisulfidesleadingtounsymmetricalorsymmetricalthiosulfonates,Chin．J．Chem．2012,inpress．SCI4．TieqiangHuang,JinchangDing,MiaochangLiu,WenxiaGao,HuayueWu,JiuxiChen,*Catalyst-freeprotocolforthesynthesisofquinoxalinesandpyrazinesinPEG,J．HeterocyclicChem．2012,inpress．SCI5．JileiZhang,JiuxiChen,*MiaochangLiu,XingwangZheng,JinchangDing,HuayueWu,*Ligand-freecopper-catalyzedcouplingofnitroareneswitharylboronicacids,GreenChem．2012,14,912-916．SCI-TOP6．ShaojinGu,BoLiu,JiuxiChen,HuayueWu,*WanChen,*Synthesis,structures,andpropertiesofruthenium(II)complexesofN-(1,10-phenanthrolin-2-yl)imidazolylidenes,DaltonTrans．2012,41,962-970．SCI-TOP7．HuiXu,WanChen,*JiuxiChen,HuayueWu,*Stereoselectivesynthesisof(Z)-1,2-dithio-1-alkenesviacopper-catalyzedthiolationof(Z)-2-bromovinylsulfides,Sythesis2012,380–388．SCI-TOP8．HongjuanDeng,YujingFang,GaoweiChen,MiaochangLiu,HuayueWu,JiuxiChen,*Copper-catalyzedClauson–Kasspyrrolessynthesisinaqueousmedia,Appl．Organometal．Chem．2012,26,164-167．SCI9．GuoweiKang,JunJiang,*HongxinLiu,HuayueWu,*Asymmetricorganocatalyticsynthesisofβ-hydroxyynoneswithaquaternarycarboncenterunderaqueousconditions,J．Braz．Chem．Soc．,2012,23,5-10．SCI10．XiepengLin,WenxiaGao,*ChenenLi,JiuxiChen,ChenYang,HuayueWu,*Nano-sizedflakecarboxymethylcassavastarchasexcipientforsoliddispersions,Int．J．Pharm．2012,423,435-439．SCI-TOP11．WeiLu,JiuxiChen,*MiaochangLiu,JinchangDing,WenxiaGao,HuayueWu,*Palladium-catalyzeddecarboxylativecouplingofisatoicanhydrideswitharylboronicacids,Org．Lett．2011,13,6114-6117．SCI-TOP12．TieqiangHuang,JunLi,JiuxiChen,*WenxiaGao,JinchangDing,HuayueWu,*Silicasulfuricacid(ssa)/pegasarecyclablesystemforthesynthesisofquinoxalinesandpyrazines,Synth．Commun．2011,41,3334–3343．SCI13．JileiZhang,JiuxiChen,*JinchangDinga,MiaochangLiu,HuayueWu,Copper-catalyzedarylationofindolin-2,3-oneswitharylboronicacids,Tetrahedron2011,67,9347-9351．SCI-TOP14．HanmeiZheng,JinchangDing,JiuxiChen,*MiaochangLiu,WenxiaGao,HuayueWu,*Copper-catalyzedarylationofarylboronicacidswithaldehydes,Synlett2011,1626-1630．SCI-TOP15．XingwangZheng,JinchangDing,JiuxiChen*,WenxiaoGao,MiaochangLiu,HuayueWu,*Thecouplingofarylboronicacidswithnitroarenescatalyzedbyrhodium．Org．Lett．2011,48,403-406．SCI-TOP16．JunLi,DannaJiang,JiuxiChen,*MiaochangLiu,JinchangDing,HuayueWu,*Eco-friendlysynthesisofquinoxalinederivativesbygrindingundersolvent-freeconditions．J．HeterocyclicChem．2011,48,403-406．SCI17．WenxiaGao,XiaoqingLin,XiepengLin,JinchangDing,XiaoboHuang,HuayueWu,*Preparationofnano-sizedflakecarboxymethylcassavastarchunderultrasonicirradiation．Carbohydr．Polym．2011,84,1413–1418．SCI18．YongPeng,JiuxiChen,*JinchangDing,MiaochangLiu,WenxiaoGao,HuayueWu,*Ligand-freecopper-catalyzedarylationofolefinsbytheMizoroki–Heckreaction．Synthesis2011,213-216．SCI-TOP19．XiepengLin,WenxiaGao*,XiaoboHuang,PanlongZang,JiuxiChen,HuayueWu,*Morphology-controlledhollownanospheresoffunctionalizeddextranbyself-assemblyinaqueoussolution．Carbohydr．Polym．2010,82,460–465．SCI20．QiangZhang,JiuxiChen,*WenxiaGao,JinchangDing,HuayueWu,*Copper-catalyzedone-potsynthesisofpropargylaminesviaC–HactivationinPEG．Appl．Organometal．Chem．2010,24,809-812．SCI21．WeixingDan,HongjuanDeng,JiuxiChen*,MiaochangLiu,JinchangDing,HuayueWu,*Anewodorlessone-potsynthesisofthioestersandselenoesterspromotedbyRongalite®,Tetrahedron2010,66,7384-7388．SCI-TOP22．WenxueGuo,GuangshuLv,JiuxiChen*,WenxiaGao,JinchangDing,HuayueWu,*Rongalite®andbase-promotedcleavageofdisulfidesandsubsequentMichaeladditiontoα,β-unsaturatedketones/esters:anodorlesssynthesisofβ-sulfidocarbonylcompounds,Tetrahedron2010,66,2297–2300．SCI-TOP23．XiaolingXu,JiuxiChen*,WenxiaGao,HuayueWu,*JinchangDing,WeikeSu,Palladium-catalyzedhydroarylationofalkyneswitharylboronicacids,Tetrahedron2010,66,2433–2438．SCI-TOP24．MingtiaoCai,GuangshuLv,JiuxiChen,*WenxiaGao,JinchangDing,HuayueWu,*CAN/I2-catalyzedChemoselectivesynthesisofthiosulfonatesbyoxidationofdisulfidesorthiols,Chem．Lett．2010,39,368-369．SCI25．ShaomiaoLin,JileiZhang,JiuxiChen,*WenxiaGao,JinchangDing,WeikeSu,HuayueWu,*AnApproachtoSynthesisofThioestersandSelenoestersPromotedbyRongalite®,J．Braz．Chem．Soc．2010,21,1616-1620．SCI26．XiaoliangYang,ChunmeiXu,ShaomiaoLin,JiuxiChen,*,JinchangDing,HuayueWu,*WeikeSu,Eco-friendlysynthesisof2-substitutedbenzothiazolescatalyzedbycetyltrimethylammoniumbromide(CTAB)inWater,J．Braz．Chem．Soc．2010,21,37-42．SCI27．ShuanghuaCheng,JiuxiChen,*WenxiaGao,HuileJin,JinchangDing,HuayueWu,*Oxidativeesterificationofaldehydeswithalcoholsandphenolsinair,J．Chem．Res．2010,130-132．SCI28．YaliXu,JiuxiChen,WenxiaGao,HuileJin,JinchangDing,HuayueWu,*Solvent-freesynthesisof3,5-di(hetero)aryl-1,2,4-thiadiazolesbygrindingofthioamidesunderoxidativeconditions．J．Chem．Res．2010,151-153．SCI29．JiuxiChen,ChangfuZhang,WenxiaGao,HuileJin,JinchangDing,HuayueWu,*B2O3/Al2O3asanew,highlyefficientandreusableheterogeneouscatalystfortheselectivesynthesisofβ-enaminoketonesandestersundersolvent-freeconditions,J．Braz．Chem．Soc．2010,21,1552-1556．SCI30．HanmeiZheng,QiangZhang,JiuxiChen,MiaochangLiu,ShuanghuaCheng,JinchangDing,*HuayueWu,*WeikeSu,Copper(II)acetate-catalyzedadditionofarylboronicacidstoaromaticaldehydes,J．Org．Chem．2009,74,943-945．SCI-TOP31．HuilongXiao,JiuxiChen,MiaochangLiu,DongjianZhu,JinchangDing,*HuayueWu,*Trichloroisocyanuricacid(TCCA)asamildandefficientcatalystforthesynthesisof2-arylbenzothiazoles,Chem．Lett．2009,38,170-171．SCI32．BingZuo,JiuxiChen,MiaochangLiu,HuayueWu,*WeikeSu,*Yb(OTf)3-catalyzedsynthesisofpyrrolesundersolvent-freeconditions,Chin．Chem．Lett．2009,20,423–426．SCI-E33．BingZuo,JiuxiChen,MiaochangLiu,JinchangDing,HuayueWu,*WeikeSu,*ScandiumTriflate-catalysedsynthesisofN-substitutedpyrrolesfromamineand2,5-dimethoxytetrahydrofuran,J．Chem．Res．2009,14-16．SCI34．DongjianZhu,JiuxiChen,MiaochangLiu,JinchangDing,HuayueWu,*Catalystandsolvent-freesynthesisofimidazo[1,2-a]pyridines,J．Braz．Chem．Soc．2009,20,482-487．SCI35．WeiXiong,JiuxiChen,MiaochangLiu,JinchangDing,HuayueWu,*WeikeSu,*AgeneralandefficientsynthesisofpyrazolescatalyzedbySc(OTf)3underSolvent-FreeConditions,J．Braz．Chem．Soc．2009,20,367-374．SCI36．TieqiangHuang,QaingZhang,JiuxiChen,*WenxiaGao,JinchangDing,HuayueWu,*Synthesisofquinoxalinescatalysedbycetyltrimethylammoniumbromide(CTAB)inaqueousmedia,J．Chem．Res．2009,761-765．SCI37．DongjianZhu,JiuxiChen,DengzeWu,MiaochangLiu,JinchangDing,HuayueWu,*AnEfficient,Catalyst-andsolvent-freesynthesisofimidazo-[1,2-a]pyridinesand2,4-disubstitutedthiazolesongrinding,J．Chem．Res．2009,84-86．SCI38．WenxueGuo,JiuxiChen*,DengzeWu,JinchangDing,FanChen,HuayueWu,*Rongalite®promotedhighlyregioselectivesynthesisofβ-hydroxysulfidesbyringopeningofepoxideswithdisulfides,Tetrahedron2009,65,5240–5243．SCI-TOP39．DongjianZhu,JiuxiChen,HuilongXiao,MiaochangLiu,JinchangDing,HuayueWu,*Efficientandexpeditioussynthesisofdi-andtrisubstitutedthiazolesinPEGundercatalyst-freeconditions,Synth．Commun．2009,39,2895–2906．SCI40．JiuxiChen,XiaoliangYang,MiaochangLiu,HuayueWu,*JinchangDing,WeikeSu,Approachtosynthesisofβ-enaminoketonesandpyrrolescatalyzedbygallium(III)triflateundersolvent-freeconditions,Synth．Commun．2009,39,4180–4198．SCI41．QiangZhang,ChunmeiXu,JiuxiChen,*XiaolingXu,JinchangDing,HuayueWu,*Palladium-catalyzedarylationofarylglyoxalswitharylboronicacids,Appl．Organometal．Chem．2009,23,524–526．SCI42．WenxueGuo,HuileJin,JiuxiChen,*,FanChen,JinchangDing,HuayueWu,*AnEfficientCatalyst-FreeProtocolfortheSynthesisofQuinoxalineDerivativesunderUltrasoundIrradiation,J．Braz．Chem．Soc．2009,20,1674-1679．SCI43．XiaoliangYang,YaliXu,JiuxiChen*,JinchangDing,HuayueWu,*WeikeSu,Sodiumdithionite-promotedsynthesisof2-arylbenzothiazolesbyreactionof2,2-disulfanediyldianilinewithaldehydesinwater,J．Chem．Res．2009,682–685．SCI44．HuilongXiao,JiuxiChen,MiaochangLiu,HuayueWu,*JinchangDing,Anapproachtodisulfidesynthesispromotedbysulfonylchlorideinsodiumbicarbonateaqueousmedia,Phosphorus,Sulfur,andSilicon,2009,184,2553–2559．SCI45．MingtiaoCai,JiuxiChen,XiaoboHuang,MiaochangLiu,JinchangDing,*HuayueWu,*Synthesisoffluorinatedβ-carbolinesbyone-potreaction,J．Chem．Res．2008,296-298．SCI46．JinchangDing,*RongXu,MiaochangLiu,Xi’anChen,HuayueWu,*GalliumtriiodideasahighlyefficientandmildcatalystforthediethylacetalizationofcarbonylcompoundsJ．IndianChem．Soc．2008,85,566-568．SCI47．ChangmingQin,HuayueWu,*JiuxiChen,MiaochangLiu,JiangCheng,*WeikeSu,JinchangDing,Palladium-catalyzedaromaticesterificationofaldehydeswithorganoboronicacidsandmolecularoxygen,Org．Lett．2008,10,1537-1540．SCI-TOP48．QiangZhang,JiuxiChen,MiaochangLiu,HuayueWu,*JiangCheng,*ChangmingQin,WeikeSu,JinchangDing,Palladium-catalyzedadditionofarylboronicacidstoN-tosylarylimines,Synlett2008,935-939．SCI-TOP49．ChangmingQin,JiuxiChen,HuayueWu,*JiangCheng,QiangZhang,BingZuo,WeikeSu,JinchangDing,One-potsynthesisofdiarylketonesfromaldehydesviapalladium-catalyzedreactionwitharylboronicacids,TetrahedronLett．2008,49,1884–1888．SCI-TOP50．JiuxiChen,DengzeWu,FeiHe,MiaochangLiu,HuayueWu,*JinchangDing,WeikeSu*,Gallium(III)triflate-catalyzedone-potselectivesynthesisof2,3-dihydro-quinazolin-4(1H)-onesandquinazolin-4(3H)-ones,TetrahedronLett．2008,49,3814-3818．SCI-TOP51．XianChen,HuayueWu,*RongXu,MiaochangLiu,JinchangDing,WeikeSu,GalliumTrichloride–promotedhighlyregioselectiveringopeningofepoxideswithNH4SCNandNaN3inwater,Synth．Commun．2008,38,1855–1865．SCI52．ChangfuZhang,JiuxiChen,XiaochunYu,XianChen,HuayueWu,*JianpingYu,B2O3/Al2O3asanefficientandrecyclablecatalystforthesynthesisofβ-aminoalcoholsundersolvent-freeconditions,Synth．Commun．2008,38,1875–1887．SCI53．FeiHe,HuayueWu,JiuxiChen,WeikeSu,UnexpectedlyhighactivityofZn(OTf)2∙6H2OincatalyticFriedel–Craftsacylationreaction,Synth．Commun．2008,38,255–264．SCI54．JiuxiChen,MiaochangLiu,XiaoliangYang,JinchangDing,HuayueWu,*Indium(III)-catalyzedsynthesisofN-substitutedpyrrolesundersolvent-freeconditions,J．Braz．Chem．Soc．2008,19,877-883．SCI55．JiuxiChen,WeikeSu,*HuayueWu,*MiaochangLiu,CanJin,Eco-friendlysynthesisof2,3-dihydroquinazolin-4(1H)-onesiniionicliquidsorionicliquid–waterwithoutadditionalcatalyst,GreenChem．2007,9,972-975．SCI-TOP56．XianChen,ChangfuZhang,HuayueWu,*XiaochunYu,WeikeSu*,JiangCheng,Solvent-freesynthesisofβ-hydroxyestersandβ-aminoestersbyindium-mediatedReformatskyreaction,Synthesis2007,3233-3239．SCI-TOP57．ChangmingQin,HuayueWu,*JiangCheng,*Xi’anChen,MiaochangLiu,WeiweiZhang,WeikeSu,JinchangDing,Thepalladium-catalyzedadditionofaryl-andheteroarylboronicacidstoaldehydes,J．Org．Chem．2007,72,-4107．SCI-TOP58．JiuxiChen,HuayueWu,*WeikeSu,Afacilesynthesisof2,3-dihydro-2-aryl-4(1H)-quinazolinonescatalyzedbyscandium(III)triflate,Chin．Chem．Lett．2007,18,536–538．SCI-E59．XianChen,HuayueWu,*WeikeSu,RongXu,MiaochangLiu,JinchangDing,Activemetallicindium-mediatedring-openingofepoxideswithdiphenyldiselenides:anovelone-potsynthesisofβ-hydroxyselenidesinaqueousmedia,J．Chem．Res．2007,325-327．SCI60．WeikeSu,*JiuxiChen,HuayueWu,CanJin,Ageneralandefficientmethodfortheselectivesynthesisofα-hydroxysulfidesandβ-hydroxysulfoxidescatalyzedbygallium(III)triflate,J．Org．Chem．2007,72,4524-4527．SCI-TOP61．JiuxiChen,HuayueWu,CanJin,XingxianZhang,YuanyuanXie,WeikeSu,*Highlyregioselectivering-openingofepoxideswiththiophenolsinionicliquidswithouttheuseofanycatalyst,GreenChem．2006,8,330–332．SCI-TOP62．JiuxiChen,HuayueWu,ZhiguoZheng,CanJin,XingxianZhang,WeikeSu,*AnapproachtothePaal–KnorrpyrrolessynthesiscatalyzedbySc(OTf)3undersolvent-freeconditions,TetrahedronLett．2006,47,5383–5387．SCI-TOP主要项目1．《基于氢键活化环氧化物的不对称开环反应研究》国家自然科学基金(21072153)，2011年1月-2013年12月，项目负责人2．《绿色化学合成技术及应用创新团队》浙江省科技创新团队(2009R50002)，2010年7月-2012年7月，子课题负责人3．《头孢、碳青霉烯系列原料药的绿色合成技术集成与示范》，国家“十一五”科技支撑计划(2007BAQ00155)，2007年8月-2010年12月，国家科技部，第二负责人4．《华基化工股份有限公司全面合作协议》，横向委托，2009年3月-2012年3月，负责人5．《头孢系列活性酯的绿色合成技术开发》，浙江省绿色化工重大专项（2006C11022），2006年6月，浙江省科学技术厅，子课题负责人6．《纺织助剂十八烷基乙烯脲的清洁生产技术开发》浙江省科技计划项目（2005C31036），2005年01月，浙江省科学技术厅，项目负责人7．《聚对芳撑乙炔类高聚物的合成、修饰及表征》，浙江省自然科学基金（Y405015），2006年01月，项目负责人8．《医药中间体2-氯苯并咪唑的合成研究》，浙江省科技计划项目（2003C31026），2003年01月，浙江省科学技术厅，项目负责人9．《吡咯酯的合成研究》，横向委托项目，2004年12月，项目负责人10．《辣椒素微胶囊的研制及其在电线、电缆护套线防鼠咬应用研究》，横向委托项目，2004年12月，项目负责人11．《炔草酯原药研制开发》，招标项目，2004年11月，项目负责人12．《邻乙氧基苯酚的高效节能、连续化清洁生产工艺研发》，横向委托，2004年11月，项目负责人专利1．吴华悦，黄小波，吴登泽，苏为科“一种2-氯苯并咪唑的化学合成方法”发明专利，ZL200710172683．9（2007-12-21）已授权2．吴华悦，吴登泽，黄小波，苏为科“一种2-羟基苯并咪唑的化学合成方法”发明专利，ZL200710172682．4（2007-12-21）已授权3．吴华悦，陈久喜，苏为科，刘妙昌“一种喹唑啉酮类化合物的合成方法”发明专利，ZL200710156597．9（2007-11-9）已授权4．吴华悦，何飞，苏为科，陈久喜“一种黄酮类化合物的化学合成方法”发明专利，ZL200810060946．1（2008-04-08）已授权学术获奖1．浙江省科学技术奖三等奖，绿色化学技术及金属试剂在有机合成中的应用研究，2009年，排名第一2．浙江省科学技术奖三等奖，含氮杂环及β-羟基类化合物的绿色合成研究，2010年，排名第四*如果发现导师信息存在错误或者偏差，欢迎随时与我们联系，以便进行更新完善。联系方式