宋欣教授电话：0531-88362883传真:0531-88565610E-mail：songx@s.e.cn;ssongxin@126.com通讯地址：山东省济南

石德利教授博士生导师0531-88364935dshi@s.e.cn教育背景1978年-1982年：山东大学生物学系动物胚胎学专业学生，1982年获得学士学位

沈月毛教授博士生导师教育背景1986年毕业于安徽师范大学化学系获学士学位，1989年毕业于中国科学院昆明植物研究所获天然产物化学硕士学位，1995年赴美国华盛顿大学化学系作访

申玉龙YulongShen，博士，教授,博士生导师通讯地址:山东大学微生物技术国家重点实验室微生物楼526室山东省济南市山大南路27号，邮编250100Tel：053

曲音波教授博士生导师院长Tel:+86-531-88365954E-mail:quyinbo@s.e.cn 教育背景曲音波，男，1953年11月生

祁庆生教授博士生导师Tel:+86-531-88365628E-mail:qiqingsheng@s.e.cn教育背景Prof.Dr.Qingsheng

庞秀华博士生导师教育背景1985-1989山东师范大学，学士1989-1992中国科学院武汉病毒研究所，硕士1996-2000华中农业大学，博士20

苗俊英教授博士生导师电话:0531-88364929E-mail:miaojy@s.e.cn基本情况苗俊英，女，出生年月：1957.11.07,博士，教授，2001被聘为博导，中国生物医学工程学会理事，中华医学会医学工程学分会干细胞工程专业委员会委员。学习和工作经历1983年毕业于武汉大学生物系，获得细胞生物学学士学位；1986年毕业于武汉大学研究生院，获得细胞生物学硕士学位。1986年9月开始在山东大学生物系细胞生物学教研室工作。1992年10月赴日本名古屋大学理学部留学，1997年9月获得该大学理学博士学位。1998年3月回山东大学生命科学学院工作。1999年9月被聘为山东大学生命科学学院教授。2001年9月被聘为山东大学生命科学学院博士生导师。2004年7月-12月，日本山口大学医学部，进行血管生理学合作研究。2007年7月-10月，香港中文大学联合院基础医学部孔祥复院士实验室，进行化学蛋白组学的合作研究。研究方向学科专业：细胞生物学；研究方向：细胞分化与转分化主要研究内容：1.血管内皮细胞增殖、分化、老化及凋亡和转分化的分子机制研究；2.血管生成的分子机制研究；3.神经干细胞和骨髓基质干细胞分化与凋亡机理研究；4.利用化学小分子研究细胞分化与凋亡的分子机制。承担课题1.利用化学小分子研究血管内皮凋亡与自噬性死亡关联的分子机制(90813022),国家自然科学基金重大研究计划资助项目.2009.01-2011.12。2.磷脂酰胆碱特异性磷酯酶C在血管内皮细胞自噬中的作用及机理研究(31070735),国家自然科学基金面上项目，2011.01-2013.12。3.化学小分子在骨髓间充质干细胞分化、老化和凋亡控制中的应用,山东大学交叉学科创新基金，2010-2012。4．动脉粥样硬化发病机制及其诊治与干预的基础研究，动脉粥样硬化斑块不稳定性和早期防治，973项目分课题（2011CB503906）。2011-2015。5.心血管重构分子机制和干预策略研究，国家自然科学基金创新研究群体（81021001），2011-2013。研究成果及发表论文发表论文（SCI）：1.LuZhang,JingZhao,LeSu,BinHuang,LiWang,HuaSu,YunZhang,ShangLiZhang,JunYingMiao*.D609inhibitsprogressionofpreexistingatheromaandpromoteslesionstabilityinapoE-/-mice:aroleofPC-PLCinatherosclerosis.ArteriosclerThrombVascBiol.2010Mar;30(3):411-8.Epub2010Feb5.(IF=7.235).2.LiWang,ZhiWuDong,BinHuang,BaoXiangZhao,HuaWang,JingZhao,,HsiangFuKung,ShangLiZhang,JunYingMiao*.DistinctPatternsofAutophagyEvokedbyTwoBenzoxazineDerivativesinVascularEndothelialCells.Autophagy,2010(IF=6.829).DOI:10.4161/auto.6.8.135083.LeSu,HongLingZhao,ChunHuiSun,BaoXiangZhao*,JingZhao,ShangLiZhang,HuaSu,JunYingMiao*.TheroleofHmbox1inendothelialdifferentiationofbone-marrowstromalcellsbyasmallmolecule.ACSChemicalBiology,2010(IF=5.108).DOI:10.1021/cb100153r4.ZhiWuDong,YiZheCheng,JingZhao,LeSu,BaoXiangZhao,YunZhang,ShangLiZhang,JunYingMiao*Discoveryofabenzoxazinederivativepromotingangiogenesisinvitroandinvivo.JCellPhysiol.2010Apr;223(1):202-8.(IF=4.586).本论文2010年7月1日获Facultyof1000Biology推荐和点评5.MengN,WuL,GaoJ,ZhaoJ,SuL,SuH,ZhangS,MiaoJ*.LipopolysaccharideincesautophagythroughBIRC2inhumanumbilicalveinendothelialcells.JCellPhysiol.2010Oct;225(1):174-9.(IF=4.586)6.SunC,LiuX,QiL,XuJ,ZhaoJ,ZhangY,ZhangS,MiaoJ*.Molationofvascularendothelialcellsenescencebyintegrinbeta4.JCellPhysiol.2010May27.[Epubaheadofprint].(IF=4.586)7.LeSu,XinLv,JiPingXu,DeLingYin,HaiYanZhang,YiLi,JingZhao,ShangLiZhang,JunYingMiao*.Neuralstemcelldifferentiationmediatedbyintegrinβ4invitro.IntJBiochemCellBiol.2009Apr;41(4):916-924.(IF=4.887).8.NanWang,ChunhuiSun,SiweiHuo,YunZhang,JingZhao,ShangliZhang,JunyingMiao*.Cooperationofphosphatidylcholine-specificphospholipaseCandbasicfibroblastgrowthfactorintheneuraldifferentiationofmesenchymalstemcellsinvitro.IntJBiochemCellBiol.2008;40(2):294-306.(IF=4.178)9.XinLv,LeSu,DelingYin,ChunhuiSun,JingZhao,ShangliZhang,JunyingMiao*.Knockdownofintegrinβ4inprimaryculturedmouseneuronsblockssurvivalandincesapoptosisbyelevatingNADPHoxidaseactivityandROSlevel.IntJBiochemCellBiol.2008；40（4）:689-699.Oct11;(IF=4.178).10.LeSu,JingZhao,BaoxiangZhao,JunyingMiao*,DelingYin,ShangliZhang.Safroleoxideincedvascularendothelialcelldifferentiationintoneuron-likecellsbydepressingthereactiveoxygenspecieslevelatthelowconcentration.BiochimicaetBiophysicaActa.2006Feb;1763(2):247-53.(IF=6.9).11.ZhaoJ,MiaoJ*,ZhaoB,ZhangS,YinD.SuppressingAktphosphorylationandactivatingFasbysafroleoxideinhibitedangiogenesisandincedvascularendothelialcellapoptosisinthepresenceoffibroblastgrowthfactor-2andserum.IntJBiochemCellBiol.2006,38(9):1603-13.(IJBCB)(IF=4.8).12.HuangB,MengN,ZhaoB*,ZhaoJ,ZhangY,ZhangS,MiaoJ*.ProtectiveEffectsofaSynthesizedButyrolactoneDerivativeagainstChloroquine-IncedAutophagicVesicleAccumulationandtheDisturbanceofMitochondrialMembranePotentialandNa(+),K(+)-ATPaseActivityinVascularEndothelialCells.Chem.Res.Toxicol.2009,22,471–475(IF=3.74)13.ChuandongFan,JingZhao,BaoxiangZhao,ShangliZhang,JunyingMiao*.Anovelcomplexofcopperandasalicylaldehydepyrazolehydrazonederivativeincesapoptosisthroughup-regulatingintegrinβ4invascularendothelialcells.Chem.Res.Toxicol.2009,22,1517–1525(IF=3.74).14.XiaLiu,DelingYin,YunZhang,JingZhao,ShangliZhang,JunyingMiao*.Vascularendothelialcellsenescencemediatedbyintegrinβ4invitro.FEBSLett.2007Nov27;581(28):5337-42.(IF=3.4).15.YizheCheng,QitaoZhao,XiaLiu,SatohikoAraki,ShangliZhang,JunyingMiao*.Phosphatidylcholine-specificphospholipaseC,p53andROSintheassociationofapoptosisandsenescenceinvascularendothelialcells.FEBSLett.2006Sep4;580(20):4911-5.(IF=3.4).16.ChunHuiSun,NanWang,JieHuang,JieXin,FenPeng,YinShiRen,ShangLiZhang,JunYingMiao*.Inhibitionofphosphatidylcholine-specificphospholipaseCpreventsbonemarrowstromalcellsenescenceinvitro.JCellBiochem.2009Jul22;108(2):519-528(IF=2.935)17.XiaLiu,JingZhao,JiPingXu,BaoXiangZhao,YunZhang,ShangLiZhangandJunYingMiao*.ProtectiveeffectsofabenzoxazinederivativeagainstoxidizedLDL-incedapoptosisandtheincreasesofintegrinβ4,ROS,NF-kBandP53invascularendothelialcells.BioorgMedChemLett.2009May15;19(10):2896-900.(IF=2.5).18.ZhiWuDong,LiWang,JiPingXu,YuLianLi,YunZhang,ShangLiZhang,JunYingMiao*.Promotionofautophagyandinhibitionofapoptosisbylowconcentrationsofcadmiuminvascularendothelialcells.ToxicolInVitro.2009Feb;23(1):105-110.(IF=2.5).19.JingZhao,QiuxiaHe,BinHuang,BaoxiangZhao*,HuaSu,ShangliZhangandJunyingMiao*.Abenzoxazinederivativeincedvascularendothelialcellapoptosisinthepresenceoffibroblastgrowthfactor-2byelevatingNADPHoxidaseactivityandreactiveoxygenspecieslevels.ToxicolInVitro.2009.23(2009)1039–1046(IF=2.5).20.SongLian,HuaSu,Bao-XiangZhao*,Wei-YongLiu,Liang-WenZheng,Jun-YingMiao*.Synthesisanddiscoveryofpyrazole-5-carbohydrazideN-glycosidesasincerofautophagyinA549lungcancercells.Bioorg.Med.Chem.17,2009,7085-7092.（IF=2.8）21.ZhengLiang-Wen,WuLing-Ling,ZhaoBao-Xiang*,DongWen-Liang,MiaoJun-Ying*.Synthesisofnovelsubstitutedpyrazole-5-carbohydrazidehydrazonederivativesanddiscoveryofapotentapoptosisincerinA549lungcancercells.Bioorg.Med.Chem.17,2009,1957-1962.（IF=2.8）22.Xiao-LingDing,Hai-YanZhang,LeiQi,Bao-XiangZhao*,SongLian,Hong-ShuiLv,Jun-YingMiao*.SynthesisofnovelpyrazolecarboxamidederivativesanddiscoveryofmolatorsforapoptosisorautophagyinA549lungcancercells.Bioorg.Med.Chem.Letters19,2009,5325-5328.（IF=2.65）23.Wei-YongLiu,Hai-YingLi,Bao-XiangZhao*,Dong-SooShin,SongLian,Jun-YingMiao*.Synthesisofnovelribavirinhydrazonederivativesandanti-proliferativeactivityagainstA549lungcancercells.CarbohydrateResearch344(2009)1270–1275.24.NingMeng,JingZhao,BaoXiangZhao,YizheCheng,WeiweiWang,YunZhang,ShangLiZhang,JunYingMiao*.AnovelbutyrolactonederivativeinhibitedsmoothmusclecellmigrationandproliferationandmaintainedendothelialcellfunctionsthroughselectivelyaffectingNa,K-ATPaseactivityandmitochondriamembranepotentialringinvitroangiogenesis.JCellBiochem.2008Aug15;104(6):2123-30.JCellBiochem.2008Aug15;104(6):2123-30.(IF=3.5).25.QiuxiaHe,BinHuang,JingZhao,YunZhang,ShangliZhang,JunyingMiao*.Knockdownofintegrinβ4-incedautophagiccelldeathassociatedwithP53inA549lungadenocarcinomacells.FEBSJ.2008Nov;275(22):5725-32.(IF=3.1).26.ZhangL,ZhuX,ZhaoB,ZhaoJ,ZhangY,ZhangS,MiaoJ*.Anovelisochromanderivativeinhibitedapoptosisinvascularendothelialcellsthroughdepressingthelevelsofintegrinbeta4,p53andROS.VasculPharmacol.2008February-March;48(2-3):63-69.（IF=2.367）.27.ZhangY,WoodruffM,ZhangY,MiaoJ,HanleyG,StuartC,ZengX,PrabhakarS,MoormanJ,ZhaoB,YinD.Toll-likereceptor4mediateschronicrestraintstress-incedimmunesuppression.JNeuroimmunol.2008Feb;194(1-2):115-22.JNeuroimmunol.2008Feb;194(1-2):115-22.28.YiZhang,YingZhang,JunyingMiao,GregoryHanley,CharlesStuart,XiuliSun,TingtingChen,andDelingYin.ChronicRestraintStressPromotesImmuneSuppressionthroughToll-likeReceptor4-MediatedPhosphoinositide3-kinaseSignaling.JNeuroimmunol.2008Nov15;204(1-2):13-9.29.LeSu,XinLv,JunYingMiao*.Integrinβ4inneuralcells.NeuromolecularMed.2008;10(4):316-21.(IF=3.4).30.Chuan-DongFan,Bao-XiangZhao*,FangWei,Gai-HuaZhang,Wen-LiangDong,Jun-YingMiao*.SynthesisanddiscoveryofautophagyincersforA549andH460lungcancercells,novel1-(2’-hydroxy-3’-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydrazidederivatives.Bioorganic&MedicinalChemistryLetters.18(2008):3860-3864.(IF=2.6).31.Jin-HuaZhang,Chuan-DongFan,Bao-XiangZhao*,Dong-SooShin,Wen-LiangDong,Yong-ShengXie,Jun-YingMiao*.Synthesisandpreliminarybiologicalevaluationofnovelpyrazolo[1,5-a]pyrazin-4(5H)-onederivativesaspotentialagentsagainstA549lungcancercells.Bioorg.Med.Chem.16，2008，10165.(IF=3.075)32.Xiao-HongPan,XiaLiu,Bao-XiangZhao*,Yong-ShengXie,Dong-SooShin,Shang-LiZhang,JingZhao,Jun-YingMiao*.5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-onederivativesinhibitgrowthoflungcancerA549cellbyincingapoptosis.BioorgMedChem.2008Oct15;16(20):9093-100.(IF=3.075).33.ZhaoBX,ZhangL,ZhuXS,WanMS,ZhaoJ,ZhangY,ZhangSL,MiaoJY*.Synthesisanddiscoveryofanovelpyrazolederivativeasaninhibitorofapoptosisthroughmolatingintegrinbeta4,ROS,andp53levelsinvascularendothelialcells.BioorgMedChem.2008May1;16(9):5171-80.(IF=3.075).34.XiaY,FanCD,ZhaoBX*,ZhaoJ,ShinDS,MiaoJY*.Synthesisandstructure-activityrelationshipsofnovel1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazidehydrazonederivativesaspotentialagentsagainstA549lungcancercells.EurJMedChem.2008Nov;43(11):2347-2353.(IF=2.187).35.Yong-ShengXie,Xiao-HongPan,Bao-XiangZhao,Jin-TingLiu,Dong-SooShin,Jin-HuaZhang,Liang-WenZheng,JingZhao,Jun-YingMiao*.Synthesis,structurecharacterizationandpreliminarybiologicalevaluationofnovel5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-onederivatives.JournalofOrganometallicChemistry693(2008)1367–1374.(IF=2.33).36.KikushimaE,NakamuraS,OshimaY,ShibuyaT,MiaoJY,HayashiH,NikaiT,ArakiS.Hemorrhagicactivityofthevascularapoptosis-incingproteinsVAP1andVAP2fromCrotalusatrox.Toxicon.2008Sep15;52(4):589-93.(IF=2.246).37.XiaY,DongZW,ZhaoBX*,GeX,MengN,ShinDS,MiaoJY*.Synthesisandstructure-activityrelationshipsofnovel1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazidederivativesaspotentialagentsagainstA549lungcancercells.BioorgMedChem.2007Nov15;15(22):6893-6899.(IF=2.6).38.NanWang,KunXie,SiweiHuo,JingZhao,ShangliZhang,JunyingMiao*.SuppressingPhosphatidylcholine-specificPhospholipaseCandelevatingROSlevel,NADPHoxidaseactivityandRblev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马翠卿教授博士生导师电话:0531-88369463E-mail:macq@s.e.cn山东大学微生物技术国家重点实验室教授。1986年毕业于华东理工大学生化工程系