学习经历原兰州大学生物系细胞生物学专业毕业，获理学硕士和博士学位，层先后在英国JOHNINNES植物研究所和瑞典GOTEBERG大学细胞与分子生物学系学习和工作过多年。曾任兰州大学细胞生

学习经历2000：兰州大学，博士；1995-1996：德国马普研究所（科隆），欧盟玛丽.居里奖学金；1987：兰州大学细胞生物学专业，硕士；1984：兰州大学生物系

学习经历2002     武汉大学        &nb

学习经历2007-2009   美国纽约大学,Skirball生物分子医学研究所，博士后Postdoctoraltraining,NewYo

学习经历◆2001.9-2005.6 兰州大学生命科学院  生物学国家基地班   学士   导师：毕玉蓉教授◆2005.9-2010.6 兰州大学和中科院上海有机化学研究所联合陪养 化学生物学 博士   导师：毕玉蓉教授，刘文研究员，唐功利研究员工作经历◆2010.9-2012.5德国saarland大学和Helmholtz研究所抗感染saar中心药物生物技术博士后   导师：RolfMüller院士，张友明教授◆2013.1至今  兰州大学生命科学院微生物所  副教授教学及指导研究生情况指导研究生4名发表论文及专著25.BiosynthesisoftheNosiheptideIndoleSideRingCentersonaCrypticCarrierProteinNosJWeiDing,WenjuanJi,YujieWu,RunzeWu,Wan-QiuLiu,TianluMo,JunfengZhao,XiaoyanMa,WeiZhang,PingXu,ZixinDeng,BopingTang*,YiYu*andQiZhang*NatureCommunications.2017Sep5;8(1):437.doi:10.1038/s41467-017-00439-124.Mechanisticstudyofthenon‐oxidativedecarboxylationcatalyzedbytheradicalS-adenosyl‐L-methionineenzymeBlsEinvolvedinblasticidinSbiosynthesisLeiLiu,XinjianJi,YongzhenLi,WenjuanJi,TianluMo,WeiDingandQiZhang*ChemicalCommunications.2017Jul3.doi:10.1039/c7cc0428623.BiosyntheticInsightsintoLinaridinNaturalProctsfromGenomeMiningandPrecursorPeptideMutagenesisTianluMo,Wan-QiuLiu,WenjuanJi,JunfengZhao,TuoChen,WeiDing,ShaoningYu*andQiZhang*ACSChemBiol.2017Jun16;12(6):1484-1488.ACSChemBiol.2017Jun16;12(6):1484-1488.doi:10.1021/acschembio.7b00262.22.Nucleoside-linkedShuntProctsintheReactionCatalyzedbytheClassCRadicalS-AdenosylmethionineMethyltransferaseNosNWeiDing,YujieWu,XinjianJi,HaochengQianzhu,FenerChen,ZixinDeng,YiYuandQiZhang*ChemicalCommunications,2017,DOI:10.1039/C7CC02162C   （IF:6.56,一区）21.CatalyticMechanismoftheClassCradicalS-AdenosylmethionineMethyltransferaseWeiDing,YongzhenLi,JunfengZhao,XinjianJi,TianluMo,HaochengQianzhu,ZixinDeng,YiYu,andQiZhang*AngewChemIntEdEngl.2017,DOI:10.1002/anie.201609948(IF:11.7)(VIPPaper)20.Reactivityofthenitrogen-centeredtryptophanylradicalinthecatalysisbytheradicalSAMenzymeNosLHaochengQianzhu,  WenjuanJi,  XinjianJi,  LeixiaChu, ChuchuGuo,  WeiLu,  WeiDing,  JiangtaoGao*and QiZhang*Chem.Commun.2016,53,344-347.(IF:6.56)19.ExpandingradicalSAMchemistrybyusingradicaladditionreactionsandSAManaloguesXinjianJi,YongzhenLi,LiqiXie,HaojieLu,WeiDing*,andQiZhang*AngewChemIntEdEngl.2016,DOI:10.1002/anie.201605917(IF:11.7)18.MechanisticstudyoftheradicalSAM-dependentaminedehydrogenationreactionsXinjianJi,Wan-QiuLiu,ShuguangYuan,YueYin,WeiDingandQiZhang*Chem.Comm.2016,DOI:10.1039/C6CC05661J(IF:6.56)17．CatalyticpromiscuityoftheradicalS-adenosyl-L-methionineenzymeNosLWeiDing,XinjianJiandYongzhenLi,andQiZhang*FrontiersinChemistry,2016,4,27.（IF:3.99）16.CharacterizationofaC3deoxygenationpathwayrevealsakeybranchpointinaminoglycosidebiosynthesisMeinanLv,XinjianJi,JunfengZhao,YongzhenLi,ChenZhang,LiSu,WeiDing,ZixinDeng,YiYu*andQiZhang*J.Am.Chem.Soc.2016,138,6427-35.(IF:13.0）15.Emergingdiversityofthecobalamin-dependentmethyltransferasesinvolvingradical-basedmechanismsWeiDing,QienLi,YouliJia,XinjianJi,HaochengQianzhu,andQiZhang*ChemBioChem,2016,DOI:10.1002/cbic.201600107(IF：2.85)14.BiosyntheticinvestigationofphomopsinsrevealedawidespreadpathwayforribosomalnaturalproctsinAscomycetesWeiDing,Wan-QiuLiu,YouliJia,YongzhenLi,WilfredAvanderDonk*,andQiZhang*Proc.Natl.Acad.Sci.2016,113,3521-6（IF：9.4）13.MechanisticInsightsintotheRadicalS-adenosyl-l-methionineEnzymeNosLFromaSubstrateAnalogueandtheShuntProcts.XianjianJi,YongzhenLi,YouliJia,WeiDing,QiZhang*AngewChemIntEdEngl.2016,55,3334-7（IF：11.7）12.Substrate-TunedCatalysisoftheRadicalS-Adenosyl-L-MethionineEnzymeNosLInvolvedinNosiheptideBiosynthesisXianjianJi,YongzhenLi,WeiDing,QiZhang*AngewChemIntEdEngl.2015,54,9021-4（IF：11.7）11.MetabolicfluxanalysisofthehalophilicarchaeonHaladaptatuspaucihalophilusGuangxiuLiu,ManxiaoZhang,TianluMo,LianHe,WeiZhang,YiYu*,QiZhang*,WeiDing*.BiochemBiophysResCommun.2015,467,1058-62（IF:2.4）10.Substrate-controlledstereochemistryinenzymecatalysisWeiDing,YongzhenLi,andQiZhang*ACSChemBiol.2015,10,1590-8(IF.5.1)9.Evolutionofthreoninealdolases,adiversefamilyinvolvedinthesecondpathwayofglycinebiosynthesisGuangxiuLiu,ManxiaoZhang,XimingChen,WeiZhang,WeiDing*,QiZhang*J.Mol.Evol.,2015,80,102-107（IF:1.8）8.AromaticPolyketidesProcedbyBacterialIterativeTypeIPolyketideSynthasesQiZhang,BoPang,WeiDing,andWenLiuACSCatal.,2013,3(7),pp1439–1447(IF：9.3)7.InsightintoBacterial6-MethylsalicyclicAcidSynthaseandItsEngineeringtoOrsellinicAcidSynthaseforNovelSpirotetronatesGeneration.WeiDing,ChunLei,QingliHe,YurongBi,WenLiu.Chemistry&Biology,2010,17,495–503(IF：5.7)(cell子刊)6.Biosynthesisof3-Methoxy-5-MethylNaphthoicAcidandItsIncorporationintotheAntitumorantibioticAzinomycinB.WeiDing,WeiDeng,ManchenTang,GongliTang,YurongBi,WenLiu.MolecularBioSystems,2010,6,1071-1081（IF：2.8）5.Nitricoxidemediatesabscisicacidincedthermotoleranceinthecallusesfromtwoecotypesofreedunderheatstress.LiliSong,WeiDing,JuanShen,ZhiguoZhang,YurongBi,LixinZhang.PlantScience,2008,175(6):826-832.（Co-firstauthor）（IF：3.4）4.Evidencefortheinvolvementofabscisicacidinheatstresstoleranceofthecallusesfromtwoecotypesofreed.WeiDing,LiliSong,YurongBi.BiologiaPlantarum,2010,54(1–4):607-613（IF：1.7）3.GeneticcharacterizationoftheSaframycinAgeneclusterfromStreptomyceslavenlaeNRRL11002revealingaNRPSsystemforthecharacteristicbisquinonebiosynthesisinaniterativemanner.LeiLi,WeiDeng,JieSong,WeiDing,Qunfei,Zhao,WeiwenSong,GongliTang,WenLiu.JournalofBacteriol,2008,290,251–263.(IF：3.2)2.CharacterizationoftheAzinomycinBBiosyntheticGeneClusterRevealingaDifferentIterativeTypeIPolyketideSynthaseforNaphthoateBiosynthesis.QunfeiZhao,QingliHe,WeiDing,ManchengTang,QianjinKang,YiYu,WeiDeng,QiZhang,JieFang,GongliTang,andWenLiu.Chemistry&Biology,2008,15,693-705.(IF：5.7)A.Nitricoxideprotectsagainstoxidativestressunderheatstressinthecallusesfromtwoecotypesofreed.LiliSong,WeiDing,MinguiZhao,BaotengSun,LixinZhang.PlantScience,2006,171(4):449-458.（IF：3.4）专利1.基因工程改造六-甲基水杨酸合成酶并组合生物合成螺环乙酰乙酸内酯类抗生素。刘文，丁伟，公开号：101812103A（有权）研究方向微生物天然产物（抗生素）的宏基因组发掘(genomemining)；极端微生物活性小分子和高效酶的发现；酶催化机制的多样性和定向进化研究；重要生物活性天然产物的生物合成机制和合成生物学研究；新型酶催化反应机制研究；重要临床药物中间体的生物催化；抗生素工业菌种的基因工程改造。

学习经历??1990.9-1994.6，兰州医学院药学系 学士1997.9-2000.6，兰州生物制品研究所微生物与免疫学专业硕士2004.9-2007.

学习经历1998.9-2001.6兰州大学生命科学学院， 硕士2001.9-2004.6兰州大学生命科学学院生，博士工作经历1993.7-至今&nb

学习经历1991.7，陇东学院生物系毕业。2001.6，兰州大学生态学专业博士博士毕业。2005.1，英国约克大学生物系，访问学者（CSC项目）。2005.12，中

学习经历1997-2001:武汉大学生命科学学院微生物专业，学士1997-2001:WuhanUniversity,Schooloflifescience,Micr