张劲松性别：男单位：茶与食品科技学院研究方向：营养与毒理；茶与健康技术职务：教授E-mail：zjs@ahau.e.cn通讯地址：合肥市长江西路130号邮政编码：230036工作经历2009．3至今安徽农业大学茶与食品科技学院2002．3─2009．2中国科学技术大学化学与材料科学学院2000．3─2002．2InstituteofFoodResearch，Norwich，UK1999．8─2000．2中国科学技术大学化学与材料科学学院1988．9─1999．7国家烟草专卖局合肥经济技术学院学习经历2002．9─2004．7中国科学院固体物理研究所博士1985．9─1988．7安徽农学院茶业系硕士1981．9─1985．7安徽农学院茶业系学士荣誉全国优秀教师第三届中国优秀青年科技创业奖研究兴趣茶与健康、茶与硒生物效应相互影响<3，4>（23，26，28），硒研究涉及硒毒性、药效、营养和酶靶。硒毒性：发明纳米硒（ZL97107038．5）并阐述其高安全性（1，2，4-6，9，13，20，24，26），基于纳米硒低毒特征，FDA毒理学研究中心前任主任邀请参编两部毒理学专著<1，2>，纳米硒为卫生部批准的保健食品，属国家级新产品。硒药效：发明硒代硫酸钠与一线化疗药顺铂联用治疗肿瘤（ZL200710023256．4），在肝癌模型上，顺铂至多取得25%治愈率，联用至少产生75%治愈率（8，15，19，25），CancerWeekly三次报道该项研究进展。硒营养：发现硒与西兰花中莱菔硫烷协同诱导硫氧还蛋白还原酶，硒与西兰花可能是防癌伴侣（3），BBCNews，TheTimes，TheGuardian，GenomicsandGeneticsWeekly，CancerWeekly等报道此发现。硒酶靶：基于动物实验，说明硫氧还蛋白还原酶是抗癌药的药靶和毒靶（7，11，12，17，18，21，27），美国ThresholdPharmaceuticals公司邀请评价抗癌新药TH-302药理，发现它抑制该酶活力（22）。专著章节<4>ZhangL,WuS,WangD,WanX,ZhangJ*.Epigallocatechin-3-gallate(EGCG)inoronnanoparticles:EnhancedstabilityandbioavailabilityofEGCGencapsulatedinnanoparticlesortargeteddeliveryofgoldnanoparticlescoatedwithEGCG.In:CascianoD,SahuSC(eds)HandbookofNanotoxicology,NanomedicineandStemCellUseinToxicology.JohnWiley&Sons.Invitedchapterinpreparation.(*communicationauthor)<3>ZhangL,ZhangZ,LuY,ZhangJ,PreedyVR.L-theaninefromgreentea:Transportandeffectsonhealth.In:PreedyVR(ed)TeainHealthandDiseasePrevention.AcademicPress.pp425-435,2012.<2>ZhangJ*,SpallholzJ.Toxicityofseleniumcompoundsandnano-seleniumparticles.In:CascianoD,SahuSC(eds)HandbookofSystemsToxicology.JohnWiley&Sons.pp787-802,2011.<1>ZhangJ*.Biologicalpropertiesofredelementalseleniumatnanosize(Nano-Se)invitroandinvivo.In:SahuSC,CascianoD(eds)Nanotoxicity:FromInVivoandInVitroModeltoHealthRisks.JohnWiley&Sons.pp97-114,2009.论文和论文评审第一或通讯作者25篇，第二作者3篇，篇均影响因子4.2，他引超过500次（WebofScience）。ChemicalReviews、JournaloftheAmericanChemicalSociety、Biomaterials等15种SCI期刊21次邀请论文评审。（28）SunK,WuS,WangY,WanX,ThompsonHJ,ZhangJ*.High-dosesodiumselenitetoxicitycannotbepreventedbytheco-administrationofpharmacologicallevelsofepigallocatechin-3-gallatewhichinturnaggravatesthetoxicity.FoodChem.Toxicol.52:36–41,2013.（27）WangY,LuH,WangD,LiS,SunK,WanX,TaylorEW,ZhangJ*.Inhibitionofglutathionesynthesiseliminatestheadaptiveresponseofascitichepatoma22cellstonedaplatinthattargetsthioredoxinrectase.Toxicol.Appl.Pharmacol.265:342-350,2012.（26）WangD,TaylorEW,WangY,WanX,ZhangJ*.Encapsulatednanoepigallocatechin-3-gallateandelementalseleniumnanoparticlesasparadigmsfornanochemoprevention.Int.J.Nanomedicine7:1711–1721,2012.（25）LiJ,SunK,NiL,WangX,WangD,ZhangJ*.Sodiumselenosulfateataninnocuousdosemarkedlypreventscisplatin-incedgastrointestinaltoxicity.Toxicol.Appl.Pharmacol.258:376-383,2012.（24）ZhangJ*,TaylorEW,WanX,PengD*.Impactofheattreatmentonsize,structure,andbioactivityofelementalseleniumnanoparticles.Int.J.Nanomedicine7:815–825,2012.（23）LuY,ZhangJ,WanX,LongM,LiD,LeiP,ZhangZ.Intestinaltransportofpuretheanineandtheanineingreenteaextract:Greenteacomponentsinhibittheanineabsorptionandpromotetheanineexcretion.FoodChem.125:277-280,2011.（22）LiS,ZhangJ*,LiJ,ChenD,MatteucciM,CurdJ,DuanJ.InhibitionofboththioredoxinrectaseandglutathionerectasemaycontributetotheanticancermechanismofTH-302.Biol.TraceElem.Res.136:294-301,2010.（21）WangX,ZhangJ*,XuT.Cyclophosphamide-evokedheartfailureinvolvespronouncedco-suppressionofcytoplasmicthioredoxinrectaseactivityandnon-proteinfreethiollevel.Eur.J.HeartFailure11:154-162,2009.（20）ZhangJ*,WangX,XuT.Elementalseleniumatnanosize(Nano-Se)asapotentialchemopreventiveagentwithrecedriskofseleniumtoxicity:comparisonwithse-methylselenocysteineinmice.Toxicol.Sci.101:22-31,2008.（19）ZhangJ*,PengD,LuH,LiuQ.Attenuatingthetoxicityofcisplatinbyusingselenosulfatewithrecedriskofseleniumtoxicityascomparedwithselenite.Toxicol.Appl.Pharmacol.226:251-259,2008.（18）ZhangJ*,WangX,LuH.Amifostineincreasescurerateofcisplatinonasciteshepatoma22viaselectivelyprotectingrenalthioredoxinrectase.CancerLett.260:127-136,2008.（17）WangX,ZhangJ*,XuT.Thioredoxinrectaseinactivationasapivotalmechanismofifosfamideincancertherapy.Eur.J.Pharmacol.579:66-73,2008.（16）ZhangJ*,WangH,PengD,TaylorEW.Furtherinsightintotheimpactofsodiumseleniteonselenoenzymes:High-doseseleniteenhanceshepaticthioredoxinrectase1activityasaconsequenceofliverinjury.Toxicol.Lett.176:223-229,2008.（15）ZhangJ*,LuH,WangX.SodiumselenosulfatesynthesisanddemonstrationofitsinvitrocytotoxicactivityagainstHepG2,Caco2andthreekindsofleukemiacells.Biol.TraceElem.Res.125:13-21,2008.（14）LiH,ZhangJ,WangT,LuoW,ZhouQ,JiangG.Elementalseleniumparticlesatnanosize(Nano-Se)aremoretoxictoMedaka(Oryziaslatipes)asaconsequenceofhyper-accumulationofselenium:Acomparisonwithsodiumselenite.Aquat.Toxicol.89:251-256,2008.（13）WangH,ZhangJ*,YuH.Elementalseleniumatnanosizepossesseslowertoxicitywithoutcompromisingthefundamentaleffectonselenoenzymes:comparisonwithselenomethionineinmice.FreeRadic.Biol.Med.42:1524-1533,2007.（12）ZhangJ*,LuH.Ifosfamideincesacuterenalfailureviainhibitionofthethioredoxinrectaseactivity.FreeRadic.Biol.Med.43:1574-1583,2007.（11）WangX,ZhangJ*,XuT.Cyclophosphamideasapotentinhibitoroftumorthioredoxinrectaseinvivo.Toxicol.Appl.Pharmacol.218:88-95,2007.（10）ZhangJ*,WangH,YuH.Thioacetamide-incedcirrhosisinselenium-adequatemicedisplaysrapidandpersistentabnormityofhepaticselenoenzymeswhicharemutetoseleniumsupplementation.Toxicol.Appl.Pharmacol.224:81-88,2007.（9）PengD,ZhangJ*,LiuQ,TaylorEW.Sizeeffectofelementalseleniumnanoparticles(Nano-Se)atsupranutritionallevelsonseleniumaccumulationandglutathioneS-transferaseactivity.J.Inorg.Biochem.101:1457-1463,2007.（8）PengD,ZhangJ*,LiuQ.Effectofsodiumselenosulfateonrestoringactivitiesofselenium-dependentenzymesandseleniumretentioncomparedwithsodiumseleniteinvitroandinvivo.Biol.TraceElem.Res.117:77-88,2007.（7）ZhangJ*,MaK,WangH.Cyclophosphamidesuppressesthioredoxinrectaseinbladdertissueanditsadaptiveresponseviainctionsofthioredoxinrectaseandglutathioneperoxidase.ChemBiol.Interact.162:24-30,2006.（6）ZhangJ*,WangH,YanX,ZhangL.Comparisonofshort-termtoxicitybetweenNano-Seandseleniteinmice.LifeSci.76:1099-1109,2005.（5）ZhangJ*,WangH,BaoY,ZhangL.Nanoredelementalseleniumhasnosizeeffectintheinctionofseleno-enzymesinbothculturedcellsandmice.LifeSci.75:237-244,2004.（4）HuangB#,ZhangJ#,HouJ,ChenC.FreeradicalscavengingefficiencyofNano-Seinvitro.FreeRadic.Biol.Med.35:805-813,2003.(#contributedequally)（3）ZhangJ,SvehlíkováV,BaoY,HowieAF,BeckettGJ,WilliamsonG.Synergybetweensulforaphaneandseleniumintheinctionofthioredoxinrectase1requiresbothtranscriptionalandtranslationalmolation.Carcinogenesis24:497-503,2003.（2）GaoX,ZhangJ,ZhangL.Hollowsphereseleniumnanoparticles:theirin-vitroantihydroxylradicaleffect.Adv.Mater.14:290-293,2002.（1）ZhangJ,GaoX,ZhangL,BaoY.Biologicaleffectsofananoredelementalselenium.Biofactors15:27-38,2001.*如果发现导师信息存在错误或者偏差，欢迎随时与我们联系，以便进行更新完善。联系方式>>